Texture-based Visualization of Metrics on Software Architectures

We present a method that combines textures, blending, and scattered-data interpolation to visualize several metrics defined on overlapping areas-of-interest on UML class diagrams. We aim to simplify the task of visually correlating the distribution and outlier values of a multivariate metric dataset with a system’s structure. We illustrate our method on a class diagram of a real-world system.

Evaluating Visual Realism in Drawing Areas of Interest on UML Diagrams

Areas of interest (AOIs) are defined as an addition to UML diagrams: groups of elements of system architecture diagrams that share some common property. Some methods have been proposed to automatically draw AOIs on UML diagrams. However, it is not clear how users perceive the results of such methods as compared to human-drawn areas of interest. We present here a process of studying and improving the perceived quality of computer-drawn AOIs. We qualitatively evaluated how users perceive the quality of computer- and human-drawn AOIs, and used these results to improve an existing algorithm for drawing AOIs. Finally, we designed a quantitative comparison for AOI drawings and used it to show that our improved renderings are closer to human drawings than the original rendering algorithm results. The combined user evaluation, algorithmic improvements, and quantitative comparison support our claim of improving the perceived quality of AOIs rendered on UML diagrams.

Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of the Netherlands'

Although genome-wide association studies (GWAS) have identified many common variants associated with complex traits, low-frequency and rare variants have not been interrogated in a comprehensive manner. Imputation from dense reference panels, such as the 1000 Genomes Project (1000G), enables testing of ungenotyped variants for association. Here we present the results of imputation using a large, new population-specific panel: the Genome of The Netherlands (GoNL). We benchmarked the performance of the 1000G and GoNL reference sets by comparing imputation genotypes with 'true' genotypes typed on ImmunoChip in three European populations (Dutch, British, and Italian). GoNL showed significant improvement in the imputation quality for rare variants (MAF 0.05-0.5%) compared with 1000G. In Dutch samples, the mean observed Pearson correlation, r 2, increased from 0.61 to 0.71. W